Estrogen signaling pathway (WP712)

Homo sapiens

Open in new tab Open in NDEx
Download PNG Download SVG Download JSON Download GPML Learn more about Downloads
Estrogen receptor refers to a group of receptors which are activated by the hormone 17-beta-estradiol (estrogen). Two types of estrogen receptor exist: ER which is a member of the nuclear hormone family of intracellular receptors and the estrogen G protein coupled receptor GPR30 (GPER), which is a G-protein coupled receptor. The main function of the estrogen receptor is as a DNA binding transcription factor which regulates gene expression. However the estrogen receptor also has additional functions independent of DNA binding. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP712 CPTAC Assay Portal]

Authors

Laura Van Zon , Kristina Hanspers , Chun Chen , Jildau Bouwman , Alex Pico , Lauren J. Dupuis , and Egon Willighagen

Activity

last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.

Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

estrogen signaling pathway

Participants
Query Drugst.One

Label Type Compact Identifier Comment
Estradiol Metabolite hmdb:HMDB0000151
Estradiol Metabolite hmdb:HMDB0000151
Estradiol Metabolite hmdb:HMDB0000151
Growth factors Metabolite hmdb:HMDB0000151
Cyclic AMP Metabolite hmdb:HMDB0000058
C-FOS GeneProduct ncbigene:2353
SP1 GeneProduct ncbigene:6667
ERE GeneProduct ncbigene:2099
ER-AF1 GeneProduct ncbigene:2099
ELK GeneProduct ncbigene:2002
ERK 1/2 GeneProduct ensembl:ENSG00000100030
ER GeneProduct ncbigene:2099
ER-AF2 GeneProduct ncbigene:2099
GPR30 GeneProduct ncbigene:2852
c-Jun GeneProduct ncbigene:3725
PI3K GeneProduct ncbigene:5290
NFKB GeneProduct ncbigene:4790
Non-ERE GeneProduct ncbigene:2099
BCL2 Apoptotic switch GeneProduct ncbigene:596
GFRs GeneProduct ncbigene:2099
GNGT1 GeneProduct ncbigene:2792
GNB1 GeneProduct ncbigene:2782
PKB/Akt GeneProduct ncbigene:207
CREB GeneProduct ncbigene:1385
MAPKKK GeneProduct ncbigene:673
JNKs GeneProduct ncbigene:5601
ER GeneProduct ncbigene:2099
GSA GeneProduct ncbigene:2778
p38 GeneProduct ncbigene:1432
MAPKK GeneProduct ensembl:ENSG00000169032
PKACA GeneProduct ncbigene:5566
NFKB GeneProduct ncbigene:4790
CREB GeneProduct ncbigene:1385
CHUK GeneProduct ncbigene:1147
ER GeneProduct ncbigene:2099
TF GeneProduct ncbigene:2099
IKBKB GeneProduct ncbigene:3551
IKBKG GeneProduct ncbigene:8517

References

  1. TAK1 is a component of the Epstein-Barr virus LMP1 complex and is essential for activation of JNK but not of NF-kappaB. Uemura N, Kajino T, Sanjo H, Sato S, Akira S, Matsumoto K, et al. J Biol Chem. 2006 Mar 24;281(12):7863–72. PubMed Europe PMC Scholia
  2. IL-1 receptor-associated kinase 1 is critical for latent membrane protein 1-induced p65/RelA serine 536 phosphorylation and NF-kappaB activation. Song YJ, Jen KY, Soni V, Kieff E, Cahir-McFarland E. Proc Natl Acad Sci U S A. 2006 Feb 21;103(8):2689–94. PubMed Europe PMC Scholia
  3. Hypoxia transcriptionally induces macrophage-inflammatory protein-3alpha/CCL-20 in primary human mononuclear phagocytes through nuclear factor (NF)-kappaB. Battaglia F, Delfino S, Merello E, Puppo M, Piva R, Varesio L, et al. J Leukoc Biol. 2008 Mar;83(3):648–62. PubMed Europe PMC Scholia