Comprehensive IL-17A signaling (WP5242)

Mus musculus

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Schematic representation of IL-17A signaling pathway with a mix of human and mouse genes/proteins based on literature review.

Authors

Rex D A B , Egon Willighagen , Kristina Hanspers , Eric Weitz , and Alex Pico

Activity

last edited

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Cited In

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Organisms

Mus musculus

Communities

Annotations

Pathway Ontology

signaling pathway interleukin-17 family mediated signaling pathway

Participants

Label Type Compact Identifier Comment
Ccl3 GeneProduct ncbigene:20302
Cxcl5 GeneProduct ncbigene:20311
Fn1 GeneProduct ncbigene:14268
Ccl5 GeneProduct ncbigene:20304
VCAN GeneProduct ncbigene:1462
TGFB1 GeneProduct ncbigene:7040
Cdc42 GeneProduct ncbigene:12540
Acta1 GeneProduct ncbigene:11459
Crebbp GeneProduct uniprot:P45481
HSPG2 GeneProduct ncbigene:3339
ACTA2 GeneProduct ncbigene:59
Cxcl1 GeneProduct ncbigene:14825
Cxcl12 GeneProduct ncbigene:20315
COL5A2 GeneProduct ncbigene:1290
Ccl4 GeneProduct ncbigene:20303
MUC5AC GeneProduct ncbigene:4586
COL3A1 GeneProduct ncbigene:1281
CXCL2 GeneProduct ncbigene:2920
Acta2 GeneProduct ncbigene:11475
Igf1 GeneProduct ncbigene:16000
Acta2 GeneProduct ncbigene:11475
Baff GeneProduct ncbigene:24099
Fbn1 GeneProduct ncbigene:14118
IL1B GeneProduct uniprot:P01584.2
Hspa1b GeneProduct ncbigene:15511
Snai1 GeneProduct uniprot:Q02085
Mki67 GeneProduct ncbigene:17345
Mcm7 GeneProduct uniprot:Q61881
Adh1 GeneProduct ncbigene:11522
Hmgb1 GeneProduct ncbigene:15289
Col1a1 GeneProduct ncbigene:12842
Pdgfb GeneProduct ncbigene:18591
Hbb-bh1 GeneProduct ncbigene:15132
Sod2 GeneProduct ncbigene:20656
Plch1 GeneProduct ncbigene:269437
CXCL5 GeneProduct ncbigene:20311
P53 GeneProduct ncbigene:22059
IL17RA GeneProduct ncbigene:23765
Prkacb GeneProduct ncbigene:18749
MAPK1 GeneProduct ncbigene:5594 p38
MAPK3 GeneProduct ncbigene:5595
Anxa6 GeneProduct ncbigene:11749
Plau GeneProduct ncbigene:18792
Il1b GeneProduct ncbigene:16176
Ptgs2 GeneProduct ncbigene:19225
CXCL6 GeneProduct ncbigene:6372
Mmp3 GeneProduct ncbigene:17392
Stat1 GeneProduct ncbigene:20846
Akt1 GeneProduct ncbigene:207
IL17A GeneProduct ncbigene:3605
Ccn2 GeneProduct ncbigene:14219
IL17RA GeneProduct ncbigene:23765
Rac1 GeneProduct ncbigene:19353
MAPK14 GeneProduct ncbigene:1432 p38
Mtor GeneProduct ncbigene:56717
Mylk GeneProduct ncbigene:107589
Gng12 GeneProduct ncbigene:14701
Uggt1 GeneProduct ncbigene:320011
Il6 GeneProduct ncbigene:16193
Mcm5 GeneProduct ncbigene:17218
Casp3 GeneProduct ncbigene:12367
Pdgfa GeneProduct ncbigene:18590
Rab10 GeneProduct ncbigene:19325
Serpine1 GeneProduct ncbigene:66870
Cpne1 GeneProduct ncbigene:266692
NFKBIA GeneProduct ncbigene:4792
C3 GeneProduct ncbigene:12266
Arpc2 GeneProduct ncbigene:76709
CXCL1 GeneProduct ncbigene:2919
NFKBIA GeneProduct ncbigene:4792
CFB GeneProduct ncbigene:629
Acta2 GeneProduct ncbigene:11475
Cxcl1 GeneProduct ncbigene:14825
Hbb-b2 GeneProduct ncbigene:15130
Col1a1 GeneProduct uniprot:P02452
Psmc6 GeneProduct ncbigene:67089
Plaur GeneProduct ncbigene:18793
Rela GeneProduct ncbigene:19697
CXCL3 GeneProduct ncbigene:2921
Ppp1r14b GeneProduct ncbigene:18938
Blmh GeneProduct ncbigene:104184
Snai2 GeneProduct uniprot:P97469
IL8 GeneProduct ncbigene:20309
Rhoa GeneProduct ncbigene:11848
Pak3 GeneProduct ncbigene:18481
GRK5 GeneProduct ncbigene:2869
Il1b GeneProduct uniprot:P10749
IL6 GeneProduct ncbigene:3569
C7 GeneProduct ncbigene:109828
Mmp14 GeneProduct ncbigene:17387
Arpc3 GeneProduct ncbigene:56378
Gap43 GeneProduct ncbigene:14432
IL17A GeneProduct ncbigene:3605
PIK3CA GeneProduct ncbigene:5290
Acta2 GeneProduct ncbigene:11475
Rras2 GeneProduct ncbigene:66922
Arpc5 GeneProduct ncbigene:67771
Atox1 GeneProduct ncbigene:11927
Hyou1 GeneProduct ncbigene:12282
Pon3 GeneProduct ensembl:ENSMUSG00000029759
Angpt1 GeneProduct ensembl:ENSMUSG00000022309
IL-17A GeneProduct ncbigene:3605
IL17RA GeneProduct ncbigene:23765
Mmp9 GeneProduct ncbigene:17395
Cxcl2 GeneProduct ncbigene:20310
Hbb-b1 GeneProduct ncbigene:15129
IL-17A GeneProduct ncbigene:3605
IL17RA GeneProduct ncbigene:23765
IL-17A GeneProduct ncbigene:3605
IL17RA GeneProduct ncbigene:23765
NFKBIA GeneProduct ncbigene:4792
ACTA2 GeneProduct ncbigene:59
IL-11 Protein uniprot:P20809
Egfr Protein uniprot:Q01279
Upf1 Protein uniprot:Q9EPU0
Zmpste24 Protein uniprot:Q80W54
Orc2 Protein uniprot:Q60862
Rbbp4 Protein uniprot:Q60972
Serpine1 Protein uniprot:P05121
TNF Protein uniprot:P01375
Srpk2 Protein uniprot:O54781
CCL2 Protein uniprot:P13500
CXCL1 Protein uniprot:P09341
Cdc42 Protein uniprot:P60766
CXCL8 Protein uniprot:P10145
Pole3 Protein uniprot:Q9JKP7
Rac1 Protein uniprot:P63001
Parp1 Protein uniprot:P11103
Plaur Protein uniprot:P35456
Casp3 Protein uniprot:P05122
Samhd1 Protein uniprot:Q60710
Cacybp Protein uniprot:Q9CXW3
CSF3 Protein uniprot:P09919
Atrx Protein uniprot:Q61687
Orc1 Protein uniprot:Q9Z1N2
IL-6 Protein uniprot:P05231
LIF Protein uniprot:P15018
Dhx9 Protein uniprot:O70133
Plau Protein uniprot:P06869
Npm1 Protein uniprot:Q61937
Nasp Protein uniprot:Q99MD9
Pcna Protein uniprot:P17918
Pura Protein uniprot:P42669
Nucks1 Protein uniprot:Q80XU3
IL-10 Protein uniprot:P22301
Sqstm1 Protein uniprot:Q64337
Map1lc3b Protein uniprot:Q9CQV6
Bcl2 Protein uniprot:P10417
Smad6 Protein uniprot:O35182
Stat1 Protein uniprot:P42225
mTOR Protein uniprot:P42345.1
Smad2 Protein ncbigene:17126
PRKAA1 Protein uniprot:Q13131
PI3KCA Protein ncbigene:5290
Becn1 Protein uniprot:O88597
Stat3 Protein uniprot:P42227
RELA Protein uniprot:Q04206
RELA Protein uniprot:Q04206
NFKB1 Protein uniprot:P19838
Map1lc3a Protein uniprot:Q91VR7
Smad7 Protein uniprot:O35253
RELA Protein uniprot:Q04206
Egfr Protein uniprot:Q01279
NFKB1 Protein uniprot:P19838
BECN1 Protein uniprot:Q14457.2
Pik3c3 Protein uniprot:Q6PF93
BCL2 Protein uniprot:P10415.2
Mcm4 Protein ncbigene:17217
Mcm6 Protein uniprot:P97311
GSK3B Protein uniprot:P49841
Mcm2 Protein uniprot:P97310
Tgfb1 Protein uniprot:P04202
P53 Protein uniprot:P04637
Mcm3 Protein uniprot:P25206
Smad3 Protein uniprot:17127
mTOR Protein uniprot:Q9JLN9
Cxcl12 Protein uniprot:P40224
Tgfb1 Protein uniprot:P04202
Smad2 Protein uniprot:Q62432
Smad3 Protein uniprot:Q8BUN5
Jak2 Protein uniprot:O60674
Jak1 Protein uniprot:P23458
Stat3 Protein uniprot:P42227
MAPK1 Protein uniprot:P28482 p38
MAPK3 Protein uniprot:P27361
mTOR Protein uniprot:Q9JLN9
Stat3 Protein uniprot:P42227
Jak2 Protein uniprot:O60674
Jak1 Protein uniprot:P23458
P53 Protein uniprot:P04637
Akt1 Protein uniprot:P31750
MAPK14 Protein uniprot:Q16539 p38
NFKB1 Protein uniprot:P19838
Smad3 Protein uniprot:Q8BUN5
Stat3 Protein uniprot:P42227
Stat1 Protein uniprot:P42225
Stat3 Protein uniprot:P42227
IL-10 Protein uniprot:P22301
BCL2 Protein uniprot:P10415.2
Snai1 Protein uniprot:Q02085
Col1a1 Protein uniprot:P02452
Snai2 Protein uniprot:P97469
Tjp1 Protein uniprot:P39447
Cdh1 Protein uniprot:P09803
Jak2 Protein uniprot:Q62120
Jak1 Protein uniprot:P52332

References

  1. A comprehensive network map of IL-17A signaling pathway. Rex DAB, Dagamajalu S, Gouda MM, Suchitha GP, Chanderasekaran J, Raju R, et al. J Cell Commun Signal. 2023 Mar;17(1):209–15. PubMed Europe PMC Scholia