Tyrobp causal network in microglia (WP3625)

Mus musculus

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The direct and indirect causal inputs upstream and downstream of Tyrobp in microglial cells. Manually translated from human model from Zhang (Cell 2013) to mouse: Gimap2 and Lgals9 (light gray) have no mouse ortholog.

Authors

Kristina Hanspers , Alex Pico , Egon Willighagen , and Eric Weitz

Activity

last edited

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Cited In

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Organisms

Mus musculus

Communities

Annotations

Pathway Ontology

innate immune response pathway Alzheimer's disease pathway

Cell Type Ontology

microglial cell

Participants

Label Type Compact Identifier Comment
Tcirg1 GeneProduct ensembl:ENSMUSG00000001750
Dpyd GeneProduct ensembl:ENSMUSG00000033308
Samsn1 GeneProduct ensembl:ENSMUSG00000022876
Il13ra1 GeneProduct ensembl:ENSMUSG00000017057
Gpx1 GeneProduct ensembl:ENSMUSG00000063856
Itgam GeneProduct ensembl:ENSMUSG00000030786
Bin2 GeneProduct ensembl:ENSMUSG00000098112
Ppp1r18 GeneProduct ensembl:ENSMUSG00000034595
Igsf6 GeneProduct ensembl:ENSMUSG00000035004
Pycard GeneProduct ensembl:ENSMUSG00000030793
Nckap1l GeneProduct ensembl:ENSMUSG00000022488
Slc1a5 GeneProduct ensembl:ENSMUSG00000001918
Fkbp15 GeneProduct ensembl:ENSMUSG00000066151
Npc2 GeneProduct ensembl:ENSMUSG00000021242
Cxcl16 GeneProduct ensembl:ENSMUSG00000018920
Tyrobp GeneProduct ensembl:ENSMUSG00000030579
Hlx GeneProduct ensembl:ENSMUSG00000039377
Cd4 GeneProduct ensembl:ENSMUSG00000023274
Abcc4 GeneProduct ensembl:ENSMUSG00000032849
Slc7a7 GeneProduct ensembl:ENSMUSG00000000958
Rbm47 GeneProduct ensembl:ENSMUSG00000070780
Apbb1ip GeneProduct ensembl:ENSMUSG00000026786
C1qc GeneProduct ensembl:ENSMUSG00000036896
Itgb2 GeneProduct ensembl:ENSMUSG00000000290
Adap2 GeneProduct ensembl:ENSMUSG00000020709
Tmem106a GeneProduct ensembl:ENSMUSG00000034947
Capg GeneProduct ensembl:ENSMUSG00000056737
Stat5a GeneProduct ensembl:ENSMUSG00000004043
Elf4 GeneProduct ensembl:ENSMUSG00000031103
Rps6ka1 GeneProduct ensembl:ENSMUSG00000003644
Spp1 GeneProduct ensembl:ENSMUSG00000029304
Creb3l2 GeneProduct ensembl:ENSMUSG00000038648
Zfp36l2 GeneProduct ensembl:ENSMUSG00000045817
Runx3 GeneProduct ensembl:ENSMUSG00000070691
Plek GeneProduct ensembl:ENSMUSG00000020120
Nrros GeneProduct ensembl:ENSMUSG00000052384
Lyl1 GeneProduct ensembl:ENSMUSG00000034041
Loxl3 GeneProduct ensembl:ENSMUSG00000000693
C3 GeneProduct ensembl:ENSMUSG00000024164
Ncf2 GeneProduct ensembl:ENSMUSG00000026480
Gapt GeneProduct ensembl:ENSMUSG00000046006
Cd37 GeneProduct ensembl:ENSMUSG00000030798
Tgfbr1 GeneProduct ensembl:ENSMUSG00000007613
Gal3st4 GeneProduct ensembl:ENSMUSG00000075593
Cd84 GeneProduct ensembl:ENSMUSG00000038147
Itgax GeneProduct ensembl:ENSMUSG00000030789
Rnase6 GeneProduct ensembl:ENSMUSG00000021880
Hcls1 GeneProduct ensembl:ENSMUSG00000022831
Il10ra GeneProduct ensembl:ENSMUSG00000032089
Sh2b3 GeneProduct ensembl:ENSMUSG00000042594
Cytl1 GeneProduct ensembl:ENSMUSG00000062329
Tnfrsf1b GeneProduct ensembl:ENSMUSG00000028599
Rgs1 GeneProduct ensembl:ENSMUSG00000026358
Il18 GeneProduct ensembl:ENSMUSG00000039217
Kcne3 GeneProduct ensembl:ENSMUSG00000035165
Sft2d2 GeneProduct ensembl:ENSMUSG00000040848
Maf GeneProduct ensembl:ENSMUSG00000055435
Lhfpl2 GeneProduct ensembl:ENSMUSG00000045312

References

  1. Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer’s disease. Zhang B, Gaiteri C, Bodea LG, Wang Z, McElwee J, Podtelezhnikov AA, et al. Cell. 2013 Apr 25;153(3):707–20. PubMed Europe PMC Scholia
  2. Fibrin-targeting immunotherapy protects against neuroinflammation and neurodegeneration. Ryu JK, Rafalski VA, Meyer-Franke A, Adams RA, Poda SB, Rios Coronado PE, et al. Nat Immunol. 2018 Nov;19(11):1212–23. PubMed Europe PMC Scholia