Metapathway biotransformation (WP1286)

Rattus norvegicus

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Biotransformation is the chemical modification (or modifications) made by an organism on a chemical compound. If this modification ends in mineral compounds like CO2, NH4+, or H2O, the biotransformation is called mineralisation. Biotransformation means chemical alteration of chemicals such as nutrients, amino acids, toxins, and drugs in the body. It is also needed to render non-polar compounds polar so that they are not reabsorbed in renal tubules and are excreted. Biotransformation of xenobiotics can dominate toxicokinetics and the metabolites may reach higher concentrations in organisms than their parent compounds.

Authors

Kristina Hanspers , Daniela Digles , and Alex Pico

Activity

last edited

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Cited In

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Organisms

Rattus norvegicus

Communities

Annotations

Pathway Ontology

cellular detoxification pathway

Participants

Label Type Compact Identifier Comment
Cyp4b1 GeneProduct ensembl:ENSRNOG00000009741
Ndst4_predicted GeneProduct ensembl:ENSRNOG00000009577
GSTA4 GeneProduct ncbigene:300850
Akr7a2 GeneProduct ensembl:ENSRNOG00000017780
NP_001102569.1 GeneProduct ensembl:ENSRNOG00000014192
NAT1 GeneProduct ncbigene:116631
SULT1C2 GeneProduct ncbigene:171072
Ugt1a3 GeneProduct ncbigene:396551
NAT2 GeneProduct ncbigene:116632
Ugt1a5 GeneProduct ncbigene:574523
NP_001100363.1 GeneProduct ensembl:ENSRNOG00000010519
Cyp27a1 GeneProduct ensembl:ENSRNOG00000017188
NP_001099210.1 GeneProduct ensembl:ENSRNOG00000027171
Cyp2u1 GeneProduct ensembl:ENSRNOG00000011053
Fmo5 GeneProduct ensembl:ENSRNOG00000018076
Ndst3_predicted GeneProduct ensembl:ENSRNOG00000015781
NP_001101680.1 GeneProduct ensembl:ENSRNOG00000014516
Gstt2 GeneProduct ensembl:ENSRNOG00000028188
Cyp4f18 GeneProduct ensembl:ENSRNOG00000015751
CYP4X1 GeneProduct ncbigene:246767
Hs3st1 GeneProduct ensembl:ENSRNOG00000010598
Mgst2 GeneProduct ensembl:ENSRNOG00000013296
HS3ST3A1 GeneProduct ncbigene:363618
Cyp4f39_predicted GeneProduct ensembl:ENSRNOG00000029478
GPX1 GeneProduct ncbigene:24404
Chst7 GeneProduct ensembl:ENSRNOG00000004258
Tpmt GeneProduct ensembl:ENSRNOG00000016468
Glyat GeneProduct ensembl:ENSRNOG00000012142
Hnmt GeneProduct ensembl:ENSRNOG00000005223
Baat GeneProduct ensembl:ENSRNOG00000007395
Fmo3 GeneProduct ensembl:ENSRNOG00000003620
Chst1 GeneProduct ensembl:ENSRNOG00000007989
Cyp24a1 GeneProduct ensembl:ENSRNOG00000013062
Chst3 GeneProduct ensembl:ENSRNOG00000000572
Sult1b1 GeneProduct ensembl:ENSRNOG00000001967
UGT1A9 GeneProduct ncbigene:396552
NP_001102193.1 GeneProduct ensembl:ENSRNOG00000007147
MGC108896 GeneProduct ensembl:ENSRNOG00000019221
GPX2 GeneProduct ncbigene:29326
CYP11B1 GeneProduct ncbigene:500892
Ugt1a1 GeneProduct ncbigene:24861
Cyp1a2 GeneProduct ensembl:ENSRNOG00000016173
AKR1B1 GeneProduct ncbigene:24192
Hs3st2 GeneProduct ensembl:ENSRNOG00000017659
NP_001101936.1 GeneProduct ensembl:ENSRNOG00000038622
Gpx3 GeneProduct ensembl:ENSRNOG00000021809
Cyp1b1 GeneProduct ensembl:ENSRNOG00000040287
Gsto1 GeneProduct ensembl:ENSRNOG00000028746
Cyp20a1 GeneProduct ensembl:ENSRNOG00000017631
LOC687052 GeneProduct ensembl:ENSRNOG00000020743
Ste GeneProduct ensembl:ENSRNOG00000001957
Cyp19a1 GeneProduct ensembl:ENSRNOG00000000196
Cyp21a1 GeneProduct ncbigene:24298
Akr7a3 GeneProduct ensembl:ENSRNOG00000017899
Cyp26c1_predicted GeneProduct ensembl:ENSRNOG00000030698
SULT2A1 GeneProduct ncbigene:24912
LOC683774 GeneProduct ensembl:ENSRNOG00000030880
CYP27B1 GeneProduct ncbigene:114700
Cyp26b1 GeneProduct ensembl:ENSRNOG00000015076
Gstt1 GeneProduct ensembl:ENSRNOG00000001242
Akr1a1 GeneProduct ensembl:ENSRNOG00000016727
Fmo1 GeneProduct ensembl:ENSRNOG00000034191
NP_001102065.1 GeneProduct ensembl:ENSRNOG00000010523
NP_001102492.1 GeneProduct ensembl:ENSRNOG00000011250
NP_001100289.1 GeneProduct ensembl:ENSRNOG00000005930
Gstm3 GeneProduct ensembl:ENSRNOG00000018937
Cyp2w1_predicted GeneProduct ensembl:ENSRNOG00000022355
NP_001101226.1 GeneProduct ensembl:ENSRNOG00000008663
CHSTB_RAT GeneProduct ensembl:ENSRNOG00000008885
Chst9 GeneProduct ncbigene:291770
Sult1c1 GeneProduct ensembl:ENSRNOG00000011269
NP_001102534.1 GeneProduct ensembl:ENSRNOG00000001375
Cyp7a1 GeneProduct ensembl:ENSRNOG00000009488
GSTZ1 GeneProduct ncbigene:681913
Chst2_predicted GeneProduct ensembl:ENSRNOG00000037453
Cyp2f2 GeneProduct ensembl:ENSRNOG00000032805
NP_001099862.1 GeneProduct ensembl:ENSRNOG00000000605
Gstk1 GeneProduct ensembl:ENSRNOG00000016484
MGC105600 GeneProduct ensembl:ENSRNOG00000028743
Hs2st1 GeneProduct ensembl:ENSRNOG00000012549
Cyp8b1 GeneProduct ensembl:ENSRNOG00000019481
Cyp1a1 GeneProduct ensembl:ENSRNOG00000019500
Gsr GeneProduct ensembl:ENSRNOG00000014915
SULT4A1 GeneProduct ncbigene:58953
HS6ST3 GeneProduct ncbigene:364476
CYP11B2 GeneProduct ncbigene:24294
GSTM5 GeneProduct ncbigene:64352
Ugt2a1 GeneProduct ensembl:ENSRNOG00000001973
Ndst1 GeneProduct ensembl:ENSRNOG00000019014
AKR1C1 GeneProduct ncbigene:307092
Kcnab1 GeneProduct ensembl:ENSRNOG00000010422
NP_001101195.1 GeneProduct ensembl:ENSRNOG00000011669
RGD1562825_predicted GeneProduct ensembl:ENSRNOG00000025930
Cyp7b1 GeneProduct ensembl:ENSRNOG00000009730
Cyp11a1 GeneProduct ensembl:ENSRNOG00000008074
Ugt2a3_predicted GeneProduct ensembl:ENSRNOG00000001975
Chst10 GeneProduct ensembl:ENSRNOG00000012815
Ephx1 GeneProduct ensembl:ENSRNOG00000003515
Nat9_predicted GeneProduct ensembl:ENSRNOG00000003264
Nat8l_predicted GeneProduct ensembl:ENSRNOG00000015466
Sult1a1 GeneProduct ensembl:ENSRNOG00000019342
NP_001099351.1 GeneProduct ensembl:ENSRNOG00000039017
Hs3st4 GeneProduct ensembl:ENSRNOG00000036723
Ugt1a6 GeneProduct ncbigene:113992
LOC690611 GeneProduct ensembl:ENSRNOG00000013604
NP_001101969.1 GeneProduct ensembl:ENSRNOG00000011367
HS3ST3B1 GeneProduct ncbigene:303218
ST2B1_RAT GeneProduct ensembl:ENSRNOG00000021046
Gss GeneProduct ensembl:ENSRNOG00000018964
Gpx5 GeneProduct ensembl:ENSRNOG00000018596
Ephx2 GeneProduct ensembl:ENSRNOG00000017286
NP_001100901.1 GeneProduct ensembl:ENSRNOG00000021521
GSTM1 GeneProduct ncbigene:24423
Kcnab3 GeneProduct ensembl:ENSRNOG00000008480
Fmo2 GeneProduct ensembl:ENSRNOG00000003510
GSTA3 GeneProduct ncbigene:24421
Kcnab2 GeneProduct ensembl:ENSRNOG00000011550
NP_001101988.1 GeneProduct ensembl:ENSRNOG00000021179
Fmo4 GeneProduct ensembl:ENSRNOG00000003400
Cyp26a1 GeneProduct ensembl:ENSRNOG00000016750
Sult1a1 GeneProduct ensembl:ENSRNOG00000019342
Cyp2e1 GeneProduct ensembl:ENSRNOG00000012458
Chst14 GeneProduct ncbigene:691394
Gm766 GeneProduct ensembl:ENSRNOG00000036959
LOC681900 GeneProduct ensembl:ENSRNOG00000014672
Cyp17a1 GeneProduct ensembl:ENSRNOG00000020035
NP_001100897.1 GeneProduct ensembl:ENSRNOG00000016953
Mgst1 GeneProduct ensembl:ENSRNOG00000007743
UGT2B17 GeneProduct ncbigene:286954
Sult1a1 GeneProduct ensembl:ENSRNOG00000019342
AKR1B10 GeneProduct ncbigene:296972
NAT8 GeneProduct ncbigene:64570
Sult1a1 GeneProduct ensembl:ENSRNOG00000019342
Ugt1a3 GeneProduct ensembl:ENSRNOG00000018740
GSTA2 GeneProduct ncbigene:24422
Gstp2 GeneProduct ensembl:ENSRNOG00000018237
Comt GeneProduct ensembl:ENSRNOG00000001889
NP_001100901.1 GeneProduct ensembl:ENSRNOG00000021521
Ugt1a2 GeneProduct ncbigene:396527
MGST3 GeneProduct ncbigene:289197
Akr1d1 GeneProduct ensembl:ENSRNOG00000013004
Gsto2 GeneProduct ensembl:ENSRNOG00000012801
Gstm5 GeneProduct ensembl:ENSRNOG00000018732
LOC685402 GeneProduct ensembl:ENSRNOG00000022982
Gstt2 GeneProduct ensembl:ENSRNOG00000028188
NP_001100974.1 GeneProduct ensembl:ENSRNOG00000022919
Cyp51 GeneProduct ensembl:ENSRNOG00000007234
CHST12 GeneProduct ncbigene:304322

References