IL-18 signaling pathway (WP4754)

Homo sapiens

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Interleukin-18 (IL-18) is a member of the IL-1 family of cytokines and was initially described as an IFN-γ-inducing factor derived from anti-CD3-stimulated Th1 cells. IL-18 plays a significant role in the activation of hematopoietic cell types mediating both Th1 and Th2 responses and is the primary inducer of interferon-γ in these cells. The biological activity of IL-18 is mediated through its binding to the IL-18 receptor complex (IL-18R) and activation of nuclear factor-kB (NF-kB), culminating in the production and release of several cytokines, chemokines, and cellular adhesion molecules. In certain cell types, IL-18 also activates mitogen-activated protein kinases (MAPKs) and PI3K/AKT signaling modules leading to the production and release of proinflammatory cytokines. IL-18 mediated signaling acts as one of the vital components of the immunomodulatory cytokine networks involved in host defense, inflammation, and tissue regeneration.

Authors

Yashwanth Subbannayya , Kristina Hanspers , Egon Willighagen , and Rex D A B

Activity

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

Interleukin mediated signaling pathway interleukin-1 signaling pathway oxidative phosphorylation pathway signaling pathway in the adaptive immune response

Participants
Query Drugst.One

Label Type Compact Identifier Comment
CYCS GeneProduct ncbigene:54205
BAX GeneProduct ncbigene:581
MAPK1 GeneProduct ncbigene:5594
IL-18BP GeneProduct ncbiprotein:10068
CASP8 GeneProduct ncbigene:841
NOX1 GeneProduct ncbigene:27035
TICAM2 GeneProduct ncbigene:353376
SLC12A3 GeneProduct ncbigene:6559
LCK GeneProduct ncbigene:3932
CYCS GeneProduct ncbigene:54205
NFKB1 GeneProduct ncbigene:4790
NCF1 GeneProduct ncbigene:653361
NCF2 GeneProduct ncbigene:4688
NCF1 GeneProduct ncbigene:653361
NCF2 GeneProduct ncbigene:4688
IMP3 GeneProduct ncbigene:55272
ELAVL1 GeneProduct ncbigene:1994
CTNNB1 GeneProduct ncbigene:1499
GSK3B GeneProduct ncbigene:2932
Protein GeneProduct ncbigene:11
AKT1 GeneProduct ncbiprotein:NP_005154.2
MAPK3 GeneProduct ncbigene:5595
CREB1 GeneProduct ncbiprotein:NP_604391.1
MAPK14 GeneProduct ncbiprotein:NP_001306.1
PIK3R1 GeneProduct ncbigene:5295
ELK1 GeneProduct ncbiprotein:NP_001107595.1
MAPK8 GeneProduct ncbiprotein:NP_620637.1
CHUK GeneProduct ncbigene:1147
IKBKB GeneProduct ncbigene:3551
RPS6 GeneProduct ncbiprotein:NP_001001.2
SRC GeneProduct ncbiprotein:NP_005408.1
NFKBIA GeneProduct ncbigene:4792
HSPB1 GeneProduct ncbigene:3315
CSN2 GeneProduct ncbigene:1447
MAP3K7 GeneProduct ncbigene:6885
GSK3A GeneProduct ncbiprotein:NP_002084.2
PTEN GeneProduct ncbigene:5728
ACACB GeneProduct ncbigene:32
JUN GeneProduct ncbiprotein:NP_002219.1
GRIN2B GeneProduct ncbigene:2904
PRKCA GeneProduct ncbigene:5578
PRKCB GeneProduct ncbigene:5579
RAF1 GeneProduct ncbiprotein:NP_001341618.1
TNFRSF1A GeneProduct ncbigene:7132
MEF2A GeneProduct ncbigene:4205
CEBPB GeneProduct ncbigene:1051
GATA1 GeneProduct ncbigene:2623
SP1 GeneProduct ncbigene:6667
CFLAR GeneProduct ncbigene:8837
BID GeneProduct ncbigene:637
CASP3 GeneProduct ncbigene:836
IRF1 GeneProduct ncbigene:3659
TNF GeneProduct ncbigene:7124
TP53 GeneProduct ncbigene:7157
FASLG GeneProduct ncbigene:356
FAS GeneProduct ncbigene:355
MAPK9 GeneProduct ncbigene:5601
Protein GeneProduct ncbigene:11
ELAVL1 GeneProduct ncbigene:1994
IMP3 GeneProduct ncbigene:55272
NFATC4 GeneProduct ncbigene:4776
NFKB1 GeneProduct ncbigene:4790
RELA GeneProduct ncbigene:5970
CTNNB1 GeneProduct ncbigene:1499
GSK3B GeneProduct ncbigene:2932
NFATC4 GeneProduct ncbigene:4776
RELA GeneProduct ncbigene:5970
IRAK4 GeneProduct ncbigene:12682231
MAP2K7 GeneProduct ncbigene:5609
STAT3 GeneProduct ncbiprotein:NP_644805.1
BAX GeneProduct ncbigene:581
AMPK1 GeneProduct ncbigene:5562
PARP1 GeneProduct ncbigene:142
RPS6KB1 GeneProduct ncbigene:6198
STAT3 GeneProduct ncbiprotein:NP_644805.1
PRKCD GeneProduct ncbigene:5580
IRAK1 Protein ncbigene:3654
TRAF6 Protein ncbigene:7189
IL18RAP Protein ncbigene:8807 IL18RAP
IL18 Protein ncbigene:3606
IL18R1 Protein ncbigene:8809
MYD88 Protein ncbigene:4615
IL37 Protein ncbigene:27178

References

  1. A comprehensive pathway map of IL-18-mediated signalling. Rex DAB, Agarwal N, Prasad TSK, Kandasamy RK, Subbannayya Y, Pinto SM. J Cell Commun Signal. 2020 Jun;14(2):257–66. PubMed Europe PMC Scholia