EGFR1 signaling pathway (WP860)

Pan troglodytes

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The androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among others, dimerize and bind to DNA. Its ligands include testosterone, dehydroepiandrosterone and androstenedione. Stimulation of the receptor activates the SMAD signaling module. Source: http://www.netpath.org/pathways?path_id=NetPath_4

Authors

Michiel Adriaens , Alex Pico , Christine Chichester , and Eric Weitz

Activity

last edited

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Organisms

Pan troglodytes

Communities

Annotations

Pathway Ontology

epidermal growth factor/neuregulin signaling pathway

Participants

Label Type Compact Identifier Comment
EGF GeneProduct ncbigene:461435
RAF1 GeneProduct ncbigene:460182
HRAS GeneProduct ncbigene:466302
NRAS GeneProduct ncbigene:742713
KRAS GeneProduct ncbigene:473387
SHOC2 GeneProduct ncbigene:466200
PIK3R1 GeneProduct ncbigene:461836
MAP3K2 GeneProduct ncbigene:736244
GRB14 GeneProduct ncbigene:459695
GRB2 GeneProduct ncbigene:737245
GRB10 GeneProduct ncbigene:463410
SOS1 GeneProduct ncbigene:459171
GRB7 GeneProduct ncbigene:454637
PIK3R2 GeneProduct ncbigene:455855
SHC1 GeneProduct ncbigene:457351
PIK3R3 GeneProduct ncbigene:456565
PIK3CA GeneProduct ncbigene:460858
PIK3CB GeneProduct ncbigene:471079
PIK3CD GeneProduct ncbigene:457922
PIK3CG GeneProduct ncbigene:463649
GAB1 GeneProduct ncbigene:461516
GAB2 GeneProduct ncbigene:748918
JAK1 GeneProduct ncbigene:743373
STAT1 GeneProduct ncbigene:459834
JAK2 GeneProduct ncbigene:464979
STAT3 GeneProduct ncbigene:454682
STAT5A GeneProduct ncbigene:454681
STAT2 GeneProduct ncbigene:451996
STAT5B GeneProduct ncbigene:454679
MAP2K1 GeneProduct ncbigene:450188
PRKCA GeneProduct ncbigene:454832
MAP3K1 GeneProduct ncbigene:471543
PRKCZ GeneProduct ncbigene:743533
PRKD1 GeneProduct ncbigene:452834
PRKCI GeneProduct ncbigene:450143
PRKCG GeneProduct ncbigene:456276
MAP2K2 GeneProduct ncbigene:456390
MAP2K3 GeneProduct ncbigene:454515
MAP2K5 GeneProduct ncbigene:453532
VAV1 GeneProduct ncbigene:455647
VAV3 GeneProduct ncbigene:457076
MAPK7 GeneProduct ncbigene:454499
MAPK1 GeneProduct ncbigene:458680
MAPK3 GeneProduct ncbigene:454037
ELK4 GeneProduct ncbigene:742304
MAPK8 GeneProduct ncbigene:450445
MAP2K7 GeneProduct ncbigene:743199
PTPRR GeneProduct ncbigene:452076
GJA1 GeneProduct ncbigene:744245
WNK1 GeneProduct ncbigene:451739
EGFR GeneProduct ncbigene:463415
KRT7 GeneProduct ncbigene:466983
KRT8 GeneProduct ncbigene:743020
KRT17 GeneProduct ncbigene:468261
KRT18 GeneProduct ncbigene:451923
SNRPD2 GeneProduct ncbigene:456134
EPPK1 GeneProduct ncbigene:464453
PLEC1 GeneProduct ncbigene:464454
PTPN12 GeneProduct ncbigene:463494
STAT3 GeneProduct ncbigene:454682
PLSCR1 GeneProduct ncbigene:460757
ERRFI1 GeneProduct ncbigene:469787
DOK2 GeneProduct ncbigene:464036
PITPNA GeneProduct ncbigene:747193
CBLB GeneProduct ncbigene:460566
PLD2 GeneProduct ncbigene:454454
PLD1 GeneProduct ncbigene:470996
PRKCA GeneProduct ncbigene:454832
EPS15 GeneProduct ncbigene:456850
EPS8 GeneProduct ncbigene:473379
HTT GeneProduct ncbigene:461084
PIK3C2B GeneProduct ncbigene:457657
SH3BGRL GeneProduct ncbigene:741160
CSK GeneProduct ncbigene:453745
REPS2 GeneProduct ncbigene:738243
RALBP1 GeneProduct ncbigene:455292
RALB GeneProduct ncbigene:750044
REPS1 GeneProduct ncbigene:463031
ABI1 GeneProduct ncbigene:450363
SOS2 GeneProduct ncbigene:452897
DNM1 GeneProduct ncbigene:464766
SH3GL3 GeneProduct ncbigene:453602
CDC42 GeneProduct ncbigene:456609
SPRY2 GeneProduct ncbigene:452616
JUND GeneProduct ncbigene:748667
FOS GeneProduct ncbigene:453047
MYC GeneProduct ncbigene:464393
CEBPB GeneProduct ncbigene:469969
PEBP1 GeneProduct ncbigene:452291
KLF11 GeneProduct ncbigene:459023
SIN3A GeneProduct ncbigene:453759
TGIF1 GeneProduct ncbigene:455312
LOC464259 GeneProduct ncbigene:464259
SH3KBP1 GeneProduct ncbigene:465527
SH3GL2 GeneProduct ncbigene:465008
JUN GeneProduct ncbigene:456893
SP1 GeneProduct ncbigene:451939
AKT1 GeneProduct ncbigene:740898
PTPN5 GeneProduct ncbigene:466462
SNCA GeneProduct ncbigene:461375
RPS6KA3 GeneProduct ncbigene:450110
AP2A1 GeneProduct ncbigene:468956
WASL GeneProduct ncbigene:463688
EEF1A1 GeneProduct ncbigene:494136
APPL1 GeneProduct ncbigene:460469
APPL2 GeneProduct ncbigene:452197
MTA2 GeneProduct ncbigene:451255
EPS15L1 GeneProduct ncbigene:455810
EPN1 GeneProduct ncbigene:737301
HIP1 GeneProduct ncbigene:750861
RFXANK GeneProduct ncbigene:455872
MAPK14 GeneProduct ncbigene:450161
TNIP1 GeneProduct ncbigene:462197
EGFR GeneProduct ncbigene:463415
EGFR GeneProduct ncbigene:463415
RBBP7 GeneProduct ncbigene:465518
ASAP1 GeneProduct ncbigene:464399
CTNND1 GeneProduct ncbigene:743685
PKN2 GeneProduct ncbigene:456998
PAK1 GeneProduct ncbigene:451439
SH2D3C GeneProduct ncbigene:464753
BCAR1 GeneProduct ncbigene:454246
CASP9 GeneProduct ncbigene:456457
RPS6KA5 GeneProduct ncbigene:739162
SMAD2 GeneProduct ncbigene:455407
SMAD3 GeneProduct ncbigene:748161
SMAD2 GeneProduct ncbigene:455407
SMAD3 GeneProduct ncbigene:748161
ATF1 GeneProduct ncbigene:452429
CREB1 GeneProduct ncbigene:459901
FOXO1 GeneProduct ncbigene:467352
PXN GeneProduct ncbigene:452303
ELF3 GeneProduct ncbigene:739176
LOC459737 GeneProduct ncbigene:459737
CAMK2A GeneProduct ncbigene:462189
ELF3 GeneProduct ncbigene:739176
RPS6KA3 GeneProduct ncbigene:450110
MAP3K2 GeneProduct ncbigene:736244
FOXO1 GeneProduct ncbigene:467352
EPS15 GeneProduct ncbigene:456850
EEF1A1 GeneProduct ncbigene:494136
STAT1 GeneProduct ncbigene:459834
STAT3 GeneProduct ncbigene:454682
STAT2 GeneProduct ncbigene:451996
STAT5A GeneProduct ncbigene:454681
ZNF259 GeneProduct ncbigene:741012
PLCG1 GeneProduct ncbigene:458253
SPRY2 GeneProduct ncbigene:452616
PLCG2 GeneProduct ncbigene:454268
PLCG2 GeneProduct ncbigene:454268
PTPN6 GeneProduct ncbigene:748032
RAF1 GeneProduct ncbigene:460182
GAB1 GeneProduct ncbigene:461516
SHC1 GeneProduct ncbigene:457351
PLD1 GeneProduct ncbigene:470996
BCAR1 GeneProduct ncbigene:454246
SH2D3C GeneProduct ncbigene:464753
APPL1 GeneProduct ncbigene:460469
APPL1 GeneProduct ncbigene:460469
APPL2 GeneProduct ncbigene:452197
STAT1 GeneProduct ncbigene:459834
SRC GeneProduct ncbigene:458229
CBL GeneProduct ncbigene:451690
CRK GeneProduct ncbigene:747142
CRKL GeneProduct ncbigene:470146
PTK2B GeneProduct ncbigene:464073
CAV1 GeneProduct ncbigene:463670
CAV2 GeneProduct ncbigene:494183
NCK1 GeneProduct ncbigene:460720
NCK2 GeneProduct ncbigene:459472
PLCG1 GeneProduct ncbigene:458253
GIT1 GeneProduct ncbigene:454549
SOCS1 GeneProduct ncbigene:737070
SOCS3 GeneProduct ncbigene:454921
INPPL1 GeneProduct ncbigene:451403
RAB5A GeneProduct ncbigene:460217
USP6NL GeneProduct ncbigene:466011
ARF4 GeneProduct ncbigene:747376
ZNF259 GeneProduct ncbigene:741012
RIPK1 GeneProduct ncbigene:462397
RALGDS GeneProduct ncbigene:464824
RASA1 GeneProduct ncbigene:461762
PRKAR1A GeneProduct ncbigene:454845
PTPN6 GeneProduct ncbigene:748032
PTPN11 GeneProduct ncbigene:748225
MAPK1 GeneProduct ncbigene:458680
MAP2K1 GeneProduct ncbigene:450188
DUSP1 GeneProduct ncbigene:471742
DUSP1 GeneProduct ncbigene:471742
ARF4 GeneProduct ncbigene:747376
ARF4 GeneProduct ncbigene:747376
EGF GeneProduct ncbigene:461435
EGF GeneProduct ncbigene:461435
SH3GL2 GeneProduct ncbigene:465008
EGFR GeneProduct ncbigene:463415

References

  1. Control of MAPK signalling: from complexity to what really matters. Hornberg JJ, Binder B, Bruggeman FJ, Schoeberl B, Heinrich R, Westerhoff HV. Oncogene. 2005 Aug 25;24(36):5533–42. PubMed Europe PMC Scholia