EGFR1 signaling pathway (WP1096)

Canis familiaris

Open in new tab
Download PNG Download SVG Download JSON Download GPML Learn more about Downloads
The androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among others, dimerize and bind to DNA. Its ligands include testosterone, dehydroepiandrosterone and androstenedione. Stimulation of the receptor activates the SMAD signaling module. Source: http://www.netpath.org/pathways?path_id=NetPath_4

Authors

Michiel Adriaens , Alex Pico , Christine Chichester , and Eric Weitz

Activity

last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.

Organisms

Canis familiaris

Communities

Annotations

Pathway Ontology

epidermal growth factor/neuregulin signaling pathway

Participants

Label Type Compact Identifier Comment
EGF GeneProduct ncbigene:403657
RAF1 GeneProduct ncbigene:484648
NRAS GeneProduct ncbigene:403872
HRAS GeneProduct ncbigene:403735
SHOC2 GeneProduct ncbigene:477819
PIK3R1 GeneProduct ncbigene:487235
MAP3K2 GeneProduct ncbigene:612902
GRB14 GeneProduct ncbigene:478770
GRB2 GeneProduct ncbigene:483312
MAP3K3 GeneProduct ncbigene:480481
SOS1 GeneProduct ncbigene:483042
GRB7 GeneProduct ncbigene:491021
PIK3R2 GeneProduct ncbigene:609956
SHC1 GeneProduct ncbigene:490439
PIK3R3 GeneProduct ncbigene:482512
PIK3CA GeneProduct ncbigene:488084
PIK3CB GeneProduct ncbigene:477085
PIK3CD GeneProduct ncbigene:489644
PIK3CG GeneProduct ncbigene:483266
GAB1 GeneProduct ncbigene:483808
GAB2 GeneProduct ncbigene:485167
JAK1 GeneProduct ncbigene:442952
STAT1 GeneProduct ncbigene:488449
JAK2 GeneProduct ncbigene:484185
STAT3 GeneProduct ncbigene:490967
STAT5A GeneProduct ncbigene:490968
STAT2 GeneProduct ncbigene:481111
STAT5B GeneProduct ncbigene:490969
MAP2K1 GeneProduct ncbigene:478347
PRKCA GeneProduct ncbigene:490904
MAP3K1 GeneProduct ncbigene:478061
PRKCZ GeneProduct ncbigene:479577
PRKD1 GeneProduct ncbigene:609091
PRKCI GeneProduct ncbigene:478686
PRKCB GeneProduct ncbigene:489968
PRKCG GeneProduct ncbigene:484316
MAP2K2 GeneProduct ncbigene:611939
MAP2K3 GeneProduct ncbigene:489547
MAP3K4 GeneProduct ncbigene:476262
VAV1 GeneProduct ncbigene:485016
VAV3 GeneProduct ncbigene:479921
VAV2 GeneProduct ncbigene:608060
MAPK7 GeneProduct ncbigene:489532
MAPK1 GeneProduct ncbigene:477575
MAPK3 GeneProduct ncbigene:486758
ELK4 GeneProduct ncbigene:488574
ELK1 GeneProduct ncbigene:491860
MAPK8 GeneProduct ncbigene:477746
MAP2K7 GeneProduct ncbigene:485004
PTPRR GeneProduct ncbigene:481163
GJA1 GeneProduct ncbigene:403418
YWHAB GeneProduct ncbigene:477237
WNK1 GeneProduct ncbigene:477728
EGFR GeneProduct ncbigene:404306
KRT7 GeneProduct ncbigene:477602
KRT8 GeneProduct ncbigene:486513
KRT17 GeneProduct ncbigene:490977
KRT18 GeneProduct ncbigene:477601
EPPK1 GeneProduct ncbigene:475117
PLEC1 GeneProduct ncbigene:482083
PTPN12 GeneProduct ncbigene:483277
STAT3 GeneProduct ncbigene:490967
PLSCR1 GeneProduct ncbigene:611500
ERRFI1 GeneProduct ncbigene:489636
DOK2 GeneProduct ncbigene:486133
PITPNA GeneProduct ncbigene:480648
CBLC GeneProduct ncbigene:612343
CBLB GeneProduct ncbigene:487965
PLD2 GeneProduct ncbigene:479473
PLD1 GeneProduct ncbigene:488167
PRKCA GeneProduct ncbigene:490904
EPS15 GeneProduct ncbigene:475356
EPS8 GeneProduct ncbigene:477686
HTT GeneProduct ncbigene:479074
PIK3C2B GeneProduct ncbigene:478938
SH3BGRL GeneProduct ncbigene:491986
CSK GeneProduct ncbigene:487649
REPS2 GeneProduct ncbigene:491756
RALBP1 GeneProduct ncbigene:490548
RALB GeneProduct ncbigene:483881
REPS1 GeneProduct ncbigene:476221
TNK2 GeneProduct ncbigene:488025
ABI1 GeneProduct ncbigene:607247
SOS2 GeneProduct ncbigene:490682
DNM1 GeneProduct ncbigene:491319
SH3GL3 GeneProduct ncbigene:609858
CDC42 GeneProduct ncbigene:607535
SPRY2 GeneProduct ncbigene:485504
JUND GeneProduct ncbigene:609409
FOS GeneProduct ncbigene:490792
MYC GeneProduct ncbigene:403924
PEBP1 GeneProduct ncbigene:477501
KLF11 GeneProduct ncbigene:475665
SIN3A GeneProduct ncbigene:478372
LOC487309 GeneProduct ncbigene:487309
SH3KBP1 GeneProduct ncbigene:612797
SH3GL2 GeneProduct ncbigene:611239
JUN GeneProduct ncbigene:609429
SP1 GeneProduct ncbigene:486507
AKT1 GeneProduct ncbigene:490878
PTPN5 GeneProduct ncbigene:485409
SNCA GeneProduct ncbigene:478478
RPS6KA1 GeneProduct ncbigene:487353
RPS6KA3 GeneProduct ncbigene:491768
RPS6KA2 GeneProduct ncbigene:612448
AP2A1 GeneProduct ncbigene:484375
WASL GeneProduct ncbigene:475213
CEACAM1 GeneProduct ncbigene:612435
EEF1A2 GeneProduct ncbigene:403506
APPL1 GeneProduct ncbigene:484716
APPL2 GeneProduct ncbigene:481297
MTA2 GeneProduct ncbigene:476057
EPS15L1 GeneProduct ncbigene:484849
EPN1 GeneProduct ncbigene:608964
HIP1 GeneProduct ncbigene:489814
RFXANK GeneProduct ncbigene:476662
MAPK14 GeneProduct ncbigene:403856
TNIP1 GeneProduct ncbigene:489178
EGFR GeneProduct ncbigene:404306
EGFR GeneProduct ncbigene:404306
RBBP7 GeneProduct ncbigene:480854
ASAP1 GeneProduct ncbigene:482044
CTNND1 GeneProduct ncbigene:483489
PKN2 GeneProduct ncbigene:490174
PAK1 GeneProduct ncbigene:607885
SH2D3C GeneProduct ncbigene:491326
BCAR1 GeneProduct ncbigene:479648
CASP9 GeneProduct ncbigene:487432
RPS6KA5 GeneProduct ncbigene:490831
SMAD2 GeneProduct ncbigene:480144
SMAD3 GeneProduct ncbigene:610902
SMAD2 GeneProduct ncbigene:480144
SMAD3 GeneProduct ncbigene:610902
ATF1 GeneProduct ncbigene:486545
CREB1 GeneProduct ncbigene:607922
FOXO1 GeneProduct ncbigene:477295
PXN GeneProduct ncbigene:486299
ELF3 GeneProduct ncbigene:490235
LOC478799 GeneProduct ncbigene:478799
CAMK2A GeneProduct ncbigene:612941
ITCH GeneProduct ncbigene:477199
ARAF GeneProduct ncbigene:491857
MCF2 GeneProduct ncbigene:492176
ELF3 GeneProduct ncbigene:490235
RPS6KA3 GeneProduct ncbigene:491768
MAP3K2 GeneProduct ncbigene:612902
FOXO1 GeneProduct ncbigene:477295
EPS15 GeneProduct ncbigene:475356
EEF1A2 GeneProduct ncbigene:403506
STAT1 GeneProduct ncbigene:488449
STAT3 GeneProduct ncbigene:490967
STAT2 GeneProduct ncbigene:481111
STAT5A GeneProduct ncbigene:490968
ZNF259 GeneProduct ncbigene:479428
PLCG1 GeneProduct ncbigene:485874
SPRY2 GeneProduct ncbigene:485504
PLCG2 GeneProduct ncbigene:489692
PLCG2 GeneProduct ncbigene:489692
PTPN6 GeneProduct ncbigene:486717
RAF1 GeneProduct ncbigene:484648
GAB1 GeneProduct ncbigene:483808
SHC1 GeneProduct ncbigene:490439
PLD1 GeneProduct ncbigene:488167
BCAR1 GeneProduct ncbigene:479648
SH2D3C GeneProduct ncbigene:491326
APPL1 GeneProduct ncbigene:484716
APPL1 GeneProduct ncbigene:484716
APPL2 GeneProduct ncbigene:481297
STAT1 GeneProduct ncbigene:488449
SRC GeneProduct ncbigene:485864
CRKL GeneProduct ncbigene:608125
NDUFA13 GeneProduct ncbigene:476659
RAC1 GeneProduct ncbigene:403955
PTK2B GeneProduct ncbigene:486102
CAV1 GeneProduct ncbigene:403980
CAV2 GeneProduct ncbigene:475294
NCK1 GeneProduct ncbigene:485677
NCK2 GeneProduct ncbigene:481319
PLCG1 GeneProduct ncbigene:485874
GIT1 GeneProduct ncbigene:491180
RGS8 GeneProduct ncbigene:490311
SOCS1 GeneProduct ncbigene:490006
SOCS3 GeneProduct ncbigene:442949
INPPL1 GeneProduct ncbigene:485209
RAB5A GeneProduct ncbigene:404008
USP6NL GeneProduct ncbigene:487132
ARF4 GeneProduct ncbigene:607073
ZNF259 GeneProduct ncbigene:479428
RIPK1 GeneProduct ncbigene:488195
MAP3K14 GeneProduct ncbigene:490926
RALGDS GeneProduct ncbigene:480686
RASA1 GeneProduct ncbigene:479158
PRKAR1A GeneProduct ncbigene:480459
PTPN6 GeneProduct ncbigene:486717
PTPN11 GeneProduct ncbigene:477488
MAPK1 GeneProduct ncbigene:477575
MAP2K1 GeneProduct ncbigene:478347
DUSP1 GeneProduct ncbigene:489117
DUSP1 GeneProduct ncbigene:489117
ARF4 GeneProduct ncbigene:607073
ARF4 GeneProduct ncbigene:607073
EGF GeneProduct ncbigene:403657
EGF GeneProduct ncbigene:403657
SH3GL2 GeneProduct ncbigene:611239
EGFR GeneProduct ncbigene:404306

References

  1. Control of MAPK signalling: from complexity to what really matters. Hornberg JJ, Binder B, Bruggeman FJ, Schoeberl B, Heinrich R, Westerhoff HV. Oncogene. 2005 Aug 25;24(36):5533–42. PubMed Europe PMC Scholia