Store-operated calcium entry proof run (WP5428)

Homo sapiens

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Depletion of endoplasmic reticulum calcium stores is sensed by STIM1, which oligomerises and gates the plasma membrane channel ORAI1, admitting calcium that is subsequently decoded by calmodulin and calcineurin in human cells.

Authors

marvinm2

Activity

last edited

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

lipid metabolic pathway

Participants
Query Drugst.One

Label Type Compact Identifier Comment
STIM1 GeneProduct ensembl:ENSG00000167323
ORAI1 GeneProduct ensembl:ENSG00000276045
CALM1 GeneProduct ensembl:ENSG00000198668
PPP3CA GeneProduct ensembl:ENSG00000138814

References

  1. The versatility and universality of calcium signalling. Berridge MJ, Lipp P, Bootman MD. Nat Rev Mol Cell Biol. 2000 Oct;1(1):11–21. PubMed Europe PMC Scholia