EGF receptor to RAS browser test (WP5427)

Homo sapiens

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Epidermal growth factor binds the EGF receptor, which recruits the guanine nucleotide exchange factor SOS1 and thereby loads KRAS with GTP, initiating downstream proliferative signalling in human cells.

Authors

marvinm2

Activity

last edited

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Organisms

Homo sapiens

Communities

Annotations

Participants
Query Drugst.One

Label Type Compact Identifier Comment
EGF GeneProduct ensembl:ENSG00000138798
EGFR GeneProduct ensembl:ENSG00000146648
SOS1 GeneProduct ensembl:ENSG00000115904
KRAS GeneProduct ensembl:ENSG00000133703

References

  1. EGF-ERBB signalling: towards the systems level. Citri A, Yarden Y. Nat Rev Mol Cell Biol. 2006 Jul;7(7):505–16. PubMed Europe PMC Scholia