Portal end-to-end check 2026-08-21 (WP5426)

Homo sapiens

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Second verification run for the portal cutover, exercising the automatic publish path. Insulin binds and activates the insulin receptor, which phosphorylates IRS1 and propagates the signal downstream to the PI3K catalytic subunit PIK3CA.

Authors

marvinm2

Activity

last edited

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Organisms

Homo sapiens

Communities

Annotations

Participants
Query Drugst.One

Label Type Compact Identifier Comment
INS GeneProduct ensembl:ENSG00000254647
INSR GeneProduct ensembl:ENSG00000171105
IRS1 GeneProduct ensembl:ENSG00000169047
PIK3CA GeneProduct ensembl:ENSG00000121879

References

  1. IRS proteins and the common path to diabetes. White MF. Am J Physiol Endocrinol Metab. 2002 Sep;283(3):E413-22. PubMed Europe PMC Scholia