Vascular smooth muscle contraction (WP2912)

Bos taurus

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Vascular smooth muscle refers to the particular type of smooth muscle found within, and composing the majority of the wall of blood vessels. The main function of vascular smooth muscle tonus is to regulate the caliber of the blood vessels in the body. Excessive vasoconstriction leads to high blood pressure, while excessive vasodilation as in shock leads to low blood pressure (http://en.wikipedia.org/wiki/Vascular_smooth_muscle).

Authors

Zahra Roudbari , Martina Summer-Kutmon , Jonathan Mélius , and Marianthi Kalafati

Activity

last edited

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Organisms

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Communities

Annotations

Pathway Ontology

regulatory pathway

Participants

Label Type Compact Identifier Comment
Ca2+ Metabolite chebi:29108
Ca2+ Metabolite chebi:29108
CAMP Metabolite chebi:17489
Angiotensin II Metabolite chebi:2719
BNP Metabolite chebi:80234
IP3 Metabolite chebi:16595
ANP Metabolite chebi:80233
PGI2 Metabolite chebi:15552
Arachidonate Metabolite chebi:15843
Norepinephrine Metabolite chebi:18357
Adrenomedullin Metabolite chebi:80339
K+ Metabolite chebi:29103
EET Metabolite chebi:34157
DAG Metabolite chebi:18035
20-HETE Metabolite chebi:34306
NO Metabolite chebi:16480
Ca2+ Metabolite chebi:29108
CNP Metabolite chebi:80235
cGMP Metabolite chebi:16356
Endothelin Metabolite chebi:80240
K+ Metabolite chebi:29103
CGRP Metabolite chebi:80337
vasopressin Metabolite chebi:34543
ADCY1 GeneProduct ncbigene:281601
ADCY9 GeneProduct ncbigene:525482
ROCK2 GeneProduct ncbigene:282041
CALM GeneProduct ncbigene:326597
CALM1 GeneProduct ncbigene:617095
PLA2G2C GeneProduct ncbigene:504978
phospholipase A2 GeneProduct ncbigene:615045
IRAG GeneProduct ncbigene:281918
GNA11 GeneProduct ncbigene:281788
CALM3 GeneProduct ncbigene:520277
PPP1CA GeneProduct ncbigene:516175
PPP1R12A GeneProduct ncbigene:538606
ADCY8 GeneProduct ncbigene:535017
ADCY2 GeneProduct ncbigene:510708
PRKCA GeneProduct ncbigene:282001
NPR-A GeneProduct ncbigene:533048
PLA2G2D4 GeneProduct ncbigene:503625
ADRA1B GeneProduct ncbigene:407140
CYP4A11 GeneProduct ncbigene:511890
RAF1 GeneProduct ncbigene:521196
ARHGEF12 GeneProduct ncbigene:503575
CACNA1D GeneProduct ncbigene:408013
MYLK4 GeneProduct ncbigene:518025
ARHGEF11 GeneProduct ncbigene:511220
KCNMB1 GeneProduct ncbigene:407176
CACNA1F GeneProduct ncbigene:509779
CYP4A22 GeneProduct ncbigene:516085
MYL6 GeneProduct ncbigene:281341
phospholipase A2 GeneProduct ncbigene:104974671
KCNMB2 GeneProduct ncbigene:534568
MYL9 GeneProduct ncbigene:505964
ITPR2 GeneProduct ncbigene:281878
ACTG2 GeneProduct ncbigene:281595
PLA2G6 GeneProduct ncbigene:535381
PRKCB GeneProduct ncbigene:282325
CALML5 GeneProduct ncbigene:520404
PLA2G4E GeneProduct ncbigene:526364
KCNMB4 GeneProduct ncbigene:520448
PLA2G4F GeneProduct ncbigene:522866
ADCY5 GeneProduct ncbigene:505740
PRKCD GeneProduct ncbigene:505708
ADCY3 GeneProduct ncbigene:535603
BRAF GeneProduct ncbigene:536051
PLCB1 GeneProduct ncbigene:287026
PRKCH GeneProduct ncbigene:518542
CACNA1C GeneProduct ensembl:ENSBTAG00000010660
PLA2G2A GeneProduct ncbigene:521383
MYLK2 GeneProduct ncbigene:533378
PLA2G10 GeneProduct ncbigene:613966
PLCB4 GeneProduct ncbigene:281985
PRKCE GeneProduct ncbigene:507041
PRKACA GeneProduct ncbigene:282322
AGTR1 GeneProduct ncbigene:281607
PTGIR GeneProduct ncbigene:520278
MAPK1 GeneProduct ncbigene:327672
MAP2K1 GeneProduct ncbigene:533199
PLCB2 GeneProduct ncbigene:508888
PLA2G2A GeneProduct ncbigene:507201
PRKX GeneProduct ncbigene:505773
ARHGEF1 GeneProduct ncbigene:513377
GUCY1A2 GeneProduct ncbigene:613600
PPP1R12C GeneProduct ncbigene:512431
PLA2G2E GeneProduct ncbigene:506243
ACTA2 GeneProduct ncbigene:515610
PLA2G2D1 GeneProduct ncbigene:494318
GNA13 GeneProduct ncbigene:505611
ITPR3 GeneProduct ncbigene:281879
PPP1CC GeneProduct ncbigene:282318
KCNMB3 GeneProduct ncbigene:539609
ADORA2B GeneProduct ncbigene:529760
PLA2G1B GeneProduct ncbigene:282457
PLCB3 GeneProduct ncbigene:515669
RAMP3 GeneProduct ncbigene:613547
NPR-B GeneProduct ncbigene:281357
ITPR1 GeneProduct ncbigene:317697
Gs GeneProduct ncbigene:281793
MYL6B GeneProduct ncbigene:515421
CPI-17 GeneProduct ncbigene:615348
RAMP2 GeneProduct ncbigene:504230
RhOA GeneProduct ncbigene:338049
PLA2G3 GeneProduct ncbigene:527631
CACNA1S GeneProduct ensembl:ENSBTAG00000047491
PRKCG GeneProduct ncbigene:282002
PRKCQ GeneProduct ncbigene:505901
GNAQ GeneProduct ncbigene:536654
CALCRL GeneProduct ncbigene:527140
PLA2G12B GeneProduct ncbigene:100337447
ADRA1A GeneProduct ncbigene:282134
ADCY7 GeneProduct ncbigene:281603
MYLK3 GeneProduct ncbigene:526379
ADORA2A GeneProduct ncbigene:617828
ROCK1 GeneProduct ncbigene:785911
CALML6 GeneProduct ncbigene:617412
MAP2K2 GeneProduct ncbigene:510434
GUCY1B3 GeneProduct ncbigene:282433
PLA2G5 GeneProduct ncbigene:614911
MAPK3 GeneProduct ncbigene:531391
ADCY6 GeneProduct ncbigene:509936
MYLK GeneProduct ncbigene:338037
KCNU1 GeneProduct ncbigene:524144
EDNRA GeneProduct ncbigene:281749
PLA2G4A GeneProduct ncbigene:525072
PRKACB GeneProduct ncbigene:282323
ADCY4 GeneProduct ncbigene:788151
PPP1CB GeneProduct ncbigene:538829
CaD GeneProduct ncbigene:281660
AVPR1B GeneProduct ncbigene:282861
ADRA1D GeneProduct ncbigene:539543
AVPR1A GeneProduct ncbigene:538439
PLA2G2F GeneProduct ncbigene:541294
KCNMA1 GeneProduct ncbigene:282573
PLA2G12A GeneProduct ncbigene:527214
GNA12 GeneProduct ncbigene:515159
RAMP1 GeneProduct ncbigene:617017
PLA2G4D GeneProduct ncbigene:531209
PLA2G4B GeneProduct ncbigene:505485
ARAF GeneProduct ncbigene:540421
CALM2 GeneProduct ncbigene:100297344
PPP1R12B GeneProduct ncbigene:100337338
GUCY1A3 GeneProduct ncbigene:281216
CACNA1F GeneProduct ncbigene:509779
CACNA1D GeneProduct ncbigene:408013
CACNA1S GeneProduct ncbigene:100337204
CACNA1C GeneProduct ncbigene:408015
KCNMB2 GeneProduct ncbigene:534568
KCNU1 GeneProduct ncbigene:524144
KCNMB3 GeneProduct ncbigene:539609
KCNMB4 GeneProduct ncbigene:520448
KCNMB1 GeneProduct ncbigene:407176
KCNMA1 GeneProduct ncbigene:282573
ITPR2 GeneProduct ncbigene:281878
ITPR1 GeneProduct ncbigene:317697
ITPR3 GeneProduct ncbigene:281879
MYLK2 GeneProduct ncbigene:533378
MYLK GeneProduct ncbigene:338037
MYLK4 GeneProduct ncbigene:518025
MYLK3 GeneProduct ncbigene:526379
ACTG2 GeneProduct ncbigene:281595
MYL6 GeneProduct ncbigene:281341
MYL9 GeneProduct ncbigene:505964
ACTA2 GeneProduct ncbigene:515610
MYL6B GeneProduct ncbigene:515421
PPP1CC GeneProduct ncbigene:282318
PPP1CB GeneProduct ncbigene:538829
PPP1R12C GeneProduct ncbigene:512431
PPP1CA GeneProduct ncbigene:516175
PPP1R12B GeneProduct ensembl:ENSBTAG00000011772
PPP1R12A GeneProduct ncbigene:538606

References